› 3eae

X-ray diffraction
2.24Å resolution

PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)

Released:
DOI: 10.2210/pdb3eae/pdb
PDB entry 3eae coloured by chain, front view.
PDB entry 3eae coloured by chain, side view.
PDB entry 3eae coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and histone binding ability characterizations of human PWWP domains.
Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J
PLoS One 6 e18919 (2011)
PMID: 21720545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182272 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatoma-derived growth factor-related protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 10.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z4V5 (Residues: 1-93; Coverage: 14%)
Gene names: HDGF2, HDGFL2, HDGFRP2, HRP2, UNQ785/PRO1604
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 41.555Å b: 59.95Å c: 104.942Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.224 0.26
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
27 more

4 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
3 more