› 3ebk

X-ray diffraction
1.9Å resolution

Crystal structure of major allergens, Bla g 4 from cockroaches

Released:
DOI: 10.2210/pdb3ebk/pdb
PDB entry 3ebk coloured by chain, front view.
PDB entry 3ebk coloured by chain, side view.
PDB entry 3ebk coloured by chain, top view.
Source organism: Blattella germanica
Primary publication:
Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
Tan YW, Chan SL, Ong TC, Yit LY, Tiong YS, Chew FT, Sivaraman J, Mok YK
J Biol Chem 284 3148-3157 (2009)
PMID: 19056737

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-157137 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Allergen Bla g 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 20.38 KDa
Source organism: Blattella germanica
Expression system: Escherichia coli
UniProt:
  • Canonical: P54962 (Residues: 7-182; Coverage: 100%)
Sequence domains: Triabin
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P41
Unit cell:
a: 60.166Å b: 60.166Å c: 124.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.253
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Indoor Allergens and Allergic Respiratory Disease.
Pomés et al. (2016)
2 more

9 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
8 more