› 3em2

X-ray diffraction
2.3Å resolution

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6038

Released:
DOI: 10.2210/pdb3em2/pdb
PDB entry 3em2 coloured by chain, front view.
PDB entry 3em2 coloured by chain, side view.
PDB entry 3em2 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Selectivity in ligand recognition of G-quadruplex loops.
Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S
Biochemistry 48 1675-80 (2009)
PMID: 19173611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116210 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*DGP*DGP*DGP*DGP*DTP*DTP*DTP*DTP*DGP*DGP*DGP*DG)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 4 x K
Ligand NCE 1 x NCE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 55.231Å b: 42.709Å c: 26.844Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.203 0.293
Expression system: Not provided

Quick links

Citations

8 review citations

Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer.
Neidle S. (2010)
7 more

6 mentions without citation

The many twists and turns of DNA: template, telomere, tool, and target.
Egli et al. (2010)
5 more