› 3emo

X-ray diffraction
3Å resolution

Crystal structure of transmembrane Hia 973-1098

Released:
DOI: 10.2210/pdb3emo/pdb
PDB entry 3emo coloured by chain, front view.
PDB entry 3emo coloured by chain, side view.
PDB entry 3emo coloured by chain, top view.
Source organism: Haemophilus influenzae
Primary publication:
Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.
Meng G, St Geme JW, Waksman G
J Mol Biol 384 824-36 (2008)
PMID: 18948113

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175334 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adhesin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 16.32 KDa
Source organism: Haemophilus influenzae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q48152 (Residues: 937-1098; Coverage: 15%)
Gene name: hia
Sequence domains:
Structure domains: GSPII I/J protein-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 194.3Å b: 45.811Å c: 56.423Å
α: 90° β: 95.12° γ: 90°
R-values:
R R work R free
0.221 0.221 0.289
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host.
Singh et al. (2012)
11 more

5 mentions without citation

Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.
Mil-Homens et al. (2011)
4 more