› 3es6

X-ray diffraction
3.23Å resolution

Crystal structure of the novel complex formed between Zinc 2-glycoprotein (ZAG) and Prolactin inducible protein (PIP) from human seminal plasma

Released:
DOI: 10.2210/pdb3es6/pdb
PDB entry 3es6 coloured by chain, front view.
PDB entry 3es6 coloured by chain, side view.
PDB entry 3es6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma.
Hassan MI, Bilgrami S, Kumar V, Singh N, Yadav S, Kaur P, Singh TP
J Mol Biol 384 663-72 (2008)
PMID: 18930737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150423 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Zinc-alpha-2-glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25311 (Residues: 21-298; Coverage: 100%)
Gene names: AZGP1, ZAG, ZNGP1
Sequence domains:
Structure domains:
Prolactin-inducible protein Chain: B
Molecule details ›
Chain: B
Length: 118 amino acids
Theoretical weight: 13.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P12273 (Residues: 29-146; Coverage: 100%)
Gene names: GCDFP15, GPIP4, PIP
Sequence domains: Seminal vesicle autoantigen (SVA)
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, NDG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand CO3 1 x CO3
Ligand P6G 1 x P6G
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P4212
Unit cell:
a: 132.298Å b: 132.298Å c: 73.752Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.196 0.24

Quick links

Citations

9 review citations

Human plasma protein N-glycosylation.
Clerc et al. (2016)
8 more

2 mentions without citation

A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch.
Amacher et al. (2015)
1 more