› 3esu

X-ray diffraction
1.3Å resolution

Crystal structure of anthrax-neutralizing single-chain antibody 14b7

Released:
DOI: 10.2210/pdb3esu/pdb
PDB entry 3esu coloured by chain, front view.
PDB entry 3esu coloured by chain, side view.
PDB entry 3esu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
Leysath CE, Monzingo AF, Maynard JA, Barnett J, Georgiou G, Iverson BL, Robertus JD
J Mol Biol 387 680-93 (2009)
PMID: 19361425

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibody 14b7* light chain and antibody 14b7* heavy chain linked with a synthetic (GGGGS)4 linker Chain: F
Molecule details ›
Chain: F
Length: 250 amino acids
Theoretical weight: 26.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P41212
Unit cell:
a: 80.176Å b: 80.176Å c: 67.825Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.236
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Immunity to ricin: fundamental insights into toxin-antibody interactions.
O'Hara et al. (2012)
4 more

3 mentions without citation

Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
Leysath et al. (2009)
2 more