› 3eu9

X-ray diffraction
1.99Å resolution

The ankyrin repeat domain of Huntingtin interacting protein 14

Released:
DOI: 10.2210/pdb3eu9/pdb
PDB entry 3eu9 coloured by chain, front view.
PDB entry 3eu9 coloured by chain, side view.
PDB entry 3eu9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding.
Gao T, Collins RE, Horton JR, Zhang X, Zhang R, Dhayalan A, Tamas R, Jeltsch A, Cheng X
Proteins 76 772-7 (2009)
PMID: 19434754

Function and Biology Details

Reaction catalysed: 
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo hexamer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Palmitoyltransferase ZDHHC17 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 240 amino acids
Theoretical weight: 26.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IUH5 (Residues: 51-288; Coverage: 38%)
Gene names: HIP14, HIP3, HSPC294, HYPH, KIAA0946, ZDHHC17
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

3 bound ligands:
Ligand HIS 1 x HIS
Ligand SO4 7 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID, null
Spacegroup: P6122
Unit cell:
a: 106.66Å b: 106.66Å c: 255.53Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.251
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.
Young et al. (2012)
2 more

7 mentions without citation

Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.
Verardi et al. (2017)
6 more