› 3euu

X-ray diffraction
2.34Å resolution

Crystal structure of the FGFR2 D2 domain

Released:
DOI: 10.2210/pdb3euu/pdb
PDB entry 3euu coloured by chain, front view.
PDB entry 3euu coloured by chain, side view.
PDB entry 3euu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sakon J, Guo F, Dakshinamurthy R, Kathir KM, Thallapuranam SKK

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-149426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 150-249; Coverage: 13%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 106.1Å b: 42.46Å c: 79.62Å
α: 90° β: 124.99° γ: 90°
R-values:
R R work R free
0.186 0.184 0.228
Expression system: Escherichia coli

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