› 3ezy

X-ray diffraction
2.04Å resolution

Crystal structure of probable dehydrogenase TM_0414 from Thermotoga maritima

Released:
DOI: 10.2210/pdb3ezy/pdb
PDB entry 3ezy coloured by chain, front view.
PDB entry 3ezy coloured by chain, side view.
PDB entry 3ezy coloured by chain, top view.
Source organism: Thermotoga maritima
Entry authors: Ramagopal UA, Toro R, Freeman J, Chang S, Maletic M, Gheyi T, Burley SK, Almo SC, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
Myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myo-inositol 2-dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 344 amino acids
Theoretical weight: 38.76 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WYP5 (Residues: 2-334; Coverage: 100%)
Gene names: TM_0414, iolG
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MRD 3 x MRD
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 69.144Å b: 108.739Å c: 98.496Å
α: 90° β: 96.26° γ: 90°
R-values:
R R work R free
0.177 0.175 0.223
Expression system: Escherichia coli

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