› 3f2n

X-ray diffraction
1.8Å resolution

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

Released:
DOI: 10.2210/pdb3f2n/pdb
PDB entry 3f2n coloured by chain, front view.
PDB entry 3f2n coloured by chain, side view.
PDB entry 3f2n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Eswaran J, Keates T, Burgess-Brown N, Fedorov O, Yue WW, Murray JW, Pike ACW, Von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase haspin Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 40.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TF76 (Residues: 465-798; Coverage: 42%)
Gene names: GSG2, HASPIN
Sequence domains: Haspin like kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand IZZ 1 x IZZ
Ligand PO4 1 x PO4
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 72.416Å b: 77.307Å c: 85.575Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.161 0.186
Expression system: Escherichia coli

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