› 3f3h

X-ray diffraction
2.1Å resolution

Crystal structure and anti-tumor activity of LZ-8 from the fungus Ganoderma lucidium

Released:
DOI: 10.2210/pdb3f3h/pdb
PDB entry 3f3h coloured by chain, front view.
PDB entry 3f3h coloured by chain, side view.
PDB entry 3f3h coloured by chain, top view.
Source organism: Ganoderma lucidum
Primary publication:
Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium.
Huang L, Sun F, Liang C, He YX, Bao R, Liu L, Zhou CZ
Proteins 75 524-7 (2009)
PMID: 19137616

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunomodulatory protein Ling Zhi-8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.52 KDa
Source organism: Ganoderma lucidum
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P14945 (Residues: 1-111; Coverage: 100%)
Sequence domains: Fungal immunomodulatory protein Fve
Structure domains: Fungal immunomodulatory protein Fve

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 33.19Å b: 86.99Å c: 92.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.221 0.246
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

From nutraceutical to clinical trial: frontiers in Ganoderma development.
Hsu et al. (2018)
4 more

6 mentions without citation

Current Understanding of the Structure and Function of Fungal Immunomodulatory Proteins.
Liu et al. (2020)
5 more