› 3f3z

X-ray diffraction
1.84Å resolution

Crystal structure of Cryptosporidium parvum calcium dependent protein kinase cgd7_1840 in presence of indirubin E804

Released:
DOI: 10.2210/pdb3f3z/pdb
PDB entry 3f3z coloured by chain, front view.
PDB entry 3f3z coloured by chain, side view.
PDB entry 3f3z coloured by chain, top view.
Source organism: Cryptosporidium parvum Iowa II
Entry authors: Wernimont AK, Lew J, Wasney G, Kozieradzki I, Cossar D, Vedadi M, Bochkarev A, Arrowsmith CH, Sundstrom M, Weigelt J, Edwards AM, Hui R, Artz JD, Amani M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
non-specific serine/threonine protein kinase Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.95 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CYL9 (Residues: 197-472; Coverage: 41%)
Gene name: cgd7_1840
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DRK 1 x DRK
Ligand GOL 4 x GOL
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 63.316Å b: 82.864Å c: 62.151Å
α: 90° β: 111.61° γ: 90°
R-values:
R R work R free
0.189 0.187 0.23
Expression system: Escherichia coli

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