› 3f4y

X-ray diffraction
2Å resolution

HIV gp41 six-helix bundle containing a mutant CHR alpha-peptide sequence

Released:
DOI: 10.2210/pdb3f4y/pdb
PDB entry 3f4y coloured by chain, front view.
PDB entry 3f4y coloured by chain, side view.
PDB entry 3f4y coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Primary publication:
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.
Horne WS, Johnson LM, Ketas TJ, Klasse PJ, Lu M, Moore JP, Gellman SH
Proc Natl Acad Sci U S A 106 14751-6 (2009)
PMID: 19706443

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137993 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 38 amino acids
Theoretical weight: 4.15 KDa
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Expression system: Not provided
UniProt:
  • Canonical: P04580 (Residues: 545-580; Coverage: 4%)
Gene name: env
Mutant peptide derived from HIV gp41 CHR domain Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 40 amino acids
Theoretical weight: 4.44 KDa
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P21212
Unit cell:
a: 37.611Å b: 179.038Å c: 33.075Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.26
Expression system: Not provided

Quick links

Citations

21 review citations

Inhibition of α-helix-mediated protein-protein interactions using designed molecules.
Azzarito et al. (2013)
20 more

10 mentions without citation

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.
Pelay-Gimeno et al. (2015)
9 more