› 3f5t

X-ray diffraction
2.7Å resolution

X-ray Structure of H5N1 NS1

Released:
DOI: 10.2210/pdb3f5t/pdb
PDB entry 3f5t coloured by chain, front view.
PDB entry 3f5t coloured by chain, side view.
PDB entry 3f5t coloured by chain, top view.
Source organism: unidentified influenza virus
Primary publication:
X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.
Bornholdt ZA, Prasad BV
Nature 456 985-8 (2008)
PMID: 18987632

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-107537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 24.25 KDa
Source organism: unidentified influenza virus
UniProt:
  • Canonical: A5A5U1 (Residues: 1-215; Coverage: 100%)
Gene names: NS, NS1
Sequence domains: Influenza non-structural protein (NS1)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6522
Unit cell:
a: 106.122Å b: 106.122Å c: 69.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.281 0.279 0.296

Quick links

Citations

24 review citations

Structures of influenza A proteins and insights into antiviral drug targets.
Das et al. (2010)
23 more

20 mentions without citation

Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins.
Heaton et al. (2013)
19 more