› 3f6y

X-ray diffraction
1.45Å resolution

Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium

Released:
DOI: 10.2210/pdb3f6y/pdb
PDB entry 3f6y coloured by chain, front view.
PDB entry 3f6y coloured by chain, side view.
PDB entry 3f6y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium.
Liu Q, Graeff R, Kriksunov IA, Lam CM, Lee HC, Hao Q
Biochemistry 47 13966-73 (2008)
PMID: 19117080

Function and Biology Details

Reactions catalysed: 
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-151306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 30.37 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 84.687Å b: 60.058Å c: 56.932Å
α: 90° β: 129.69° γ: 90°
R-values:
R R work R free
0.148 0.146 0.184
Expression system: Komagataella pastoris

Quick links

Citations

1 review citation

Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.
Lee HC. (2011)
5 other articles

3 mentions without citation

Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium.
Liu et al. (2008)
2 more