› 3f70

X-ray diffraction
2.1Å resolution

Crystal structure of L3MBTL2-H4K20me1 complex

Released:
DOI: 10.2210/pdb3f70/pdb
PDB entry 3f70 coloured by chain, front view.
PDB entry 3f70 coloured by chain, side view.
PDB entry 3f70 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.
Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J
Nucleic Acids Res 37 2204-10 (2009)
PMID: 19233876

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lethal(3)malignant brain tumor-like protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 456 amino acids
Theoretical weight: 52.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q969R5 (Residues: 170-625; Coverage: 65%)
Gene name: L3MBTL2
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

1 bound ligand:
Ligand MLZ 2 x MLZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 55.59Å b: 55.489Å c: 324.101Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.199 0.268
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
17 more

6 mentions without citation

MBT domain proteins in development and disease.
Bonasio et al. (2010)
5 more