› 3fbk

X-ray diffraction
2Å resolution

Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A

Released:
DOI: 10.2210/pdb3fbk/pdb
PDB entry 3fbk coloured by chain, front view.
PDB entry 3fbk coloured by chain, side view.
PDB entry 3fbk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Forouhar F, Lew S, Seetharaman J, Mao L, Xiao R, Ciccosanti C, Foote EL, Shastry R, Everett JK, Nair R, Acton TB, Rost B, Montelione GT, Hunt JF, Tong L, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156047 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 153 amino acids
Theoretical weight: 17.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49796 (Residues: 134-276; Coverage: 12%)
Gene name: RGS3
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 44.661Å b: 77.171Å c: 44.681Å
α: 90° β: 115.07° γ: 90°
R-values:
R R work R free
0.199 0.198 0.253
Expression system: Escherichia coli

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