› 3fg7

X-ray diffraction
2Å resolution

The crystal structure of villin domain 6

Released:
DOI: 10.2210/pdb3fg7/pdb
PDB entry 3fg7 coloured by chain, front view.
PDB entry 3fg7 coloured by chain, side view.
PDB entry 3fg7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Helix straightening as an activation mechanism in the gelsolin superfamily of actin regulatory proteins.
Wang H, Chumnarnsilpa S, Loonchanta A, Li Q, Kuan YM, Robine S, Larsson M, Mihalek I, Burtnick LD, Robinson RC
J Biol Chem 284 21265-9 (2009)
PMID: 19491107

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Villin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 398 amino acids
Theoretical weight: 44.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09327 (Residues: 360-720; Coverage: 44%)
Gene names: VIL, VIL1
Sequence domains: Gelsolin repeat
Structure domains: Severin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P31
Unit cell:
a: 47.82Å b: 47.82Å c: 98.173Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.197 0.246
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides.
Saarikangas et al. (2010)
5 more

5 mentions without citation

Towards functional characterization of archaeal genomic dark matter.
Makarova et al. (2019)
4 more