› 3fke

X-ray diffraction
1.4Å resolution

Structure of the Ebola VP35 Interferon Inhibitory Domain

Released:
DOI: 10.2210/pdb3fke/pdb
PDB entry 3fke coloured by chain, front view.
PDB entry 3fke coloured by chain, side view.
PDB entry 3fke coloured by chain, top view.
Source organism: Ebola virus - Mayinga, Zaire, 1976
Primary publication:
Structure of the Ebola VP35 interferon inhibitory domain.
Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK
Proc Natl Acad Sci U S A 106 411-6 (2009)
PMID: 19122151

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase cofactor VP35 Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.21 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05127 (Residues: 215-340; Coverage: 37%)
Gene name: VP35
Sequence domains: Filoviridae VP35
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 51.49Å b: 66.21Å c: 72.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.198 0.236
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Evasion of interferon responses by Ebola and Marburg viruses.
Basler et al. (2009)
27 more

36 mentions without citation

Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.
Hastie et al. (2012)
35 more