› 3fpt

X-ray diffraction
2.7Å resolution

The Crystal Structure of the Complex between Evasin-1 and CCL3

Released:
DOI: 10.2210/pdb3fpt/pdb
PDB entry 3fpt coloured by chain, front view.
PDB entry 3fpt coloured by chain, side view.
PDB entry 3fpt coloured by chain, top view.
Source organism: Rhipicephalus sanguineus
Primary publication:
Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3.
Dias JM, Losberger C, Déruaz M, Power CA, Proudfoot AE, Shaw JP
PLoS One 4 e8514 (2009)
PMID: 20041127

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Evasin-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 100 amino acids
Theoretical weight: 11.31 KDa
Source organism: Rhipicephalus sanguineus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0C8E7 (Residues: 21-114; Coverage: 100%)
Sequence domains: Evasins Class A
Structure domains: Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 68.704Å b: 70.491Å c: 103.819Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.226 0.305
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Bachelerie et al. (2014)
9 more

2 mentions without citation

Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines.
Bhusal et al. (2020)
1 more