› 3fva

X-ray diffraction
1.46Å resolution

NNQNTF segment from elk prion

Released:
DOI: 10.2210/pdb3fva/pdb
PDB entry 3fva coloured by chain, front view.
PDB entry 3fva coloured by chain, side view.
PDB entry 3fva coloured by chain, top view.
Source organism: Cervus canadensis nelsoni
Primary publication:
Molecular mechanisms for protein-encoded inheritance.
Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D
Nat Struct Mol Biol 16 973-8 (2009)
PMID: 19684598

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159267 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 737 Da
Source organism: Cervus canadensis nelsoni
Expression system: Not provided
UniProt:
  • Canonical: P67986 (Residues: 173-178; Coverage: 3%)
Gene names: PRNP, PRP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 18.061Å b: 4.84Å c: 21.362Å
α: 90° β: 100.1° γ: 90°
R-values:
R R work R free
0.163 0.162 0.174
Expression system: Not provided

Quick links

Citations

41 review citations

The amyloid state of proteins in human diseases.
Eisenberg et al. (2012)
40 more

11 mentions without citation

The Three-Dimensional Structures of Amyloids.
Riek R. (2017)
10 more