› 3fw1

X-ray diffraction
1.75Å resolution

Quinone Reductase 2

Released:
DOI: 10.2210/pdb3fw1/pdb
PDB entry 3fw1 coloured by chain, front view.
PDB entry 3fw1 coloured by chain, side view.
PDB entry 3fw1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Winger JA, Hantschel O, Superti-Furga G, Kuriyan J
BMC Struct Biol 9 7 (2009)
PMID: 19236722

Function and Biology Details

Reaction catalysed: 
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosyldihydronicotinamide dehydrogenase [quinone] Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 26.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16083 (Residues: 1-231; Coverage: 100%)
Gene names: NMOR2, NQO2
Sequence domains: Flavodoxin-like fold
Structure domains: Rossmann fold

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
3 bound ligands:
Ligand ZN 1 x ZN
Ligand STI 1 x STI
Ligand MRD 2 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I422
Unit cell:
a: 100.337Å b: 100.337Å c: 104.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.15 0.182
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Target profiling of small molecules by chemical proteomics.
Rix et al. (2009)
8 more

7 mentions without citation

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Winger et al. (2009)
6 more