› 3g51

X-ray diffraction
1.8Å resolution

Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2

Released:
DOI: 10.2210/pdb3g51/pdb
PDB entry 3g51 coloured by chain, front view.
PDB entry 3g51 coloured by chain, side view.
PDB entry 3g51 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.
Malakhova M, Kurinov I, Liu K, Zheng D, D'Angelo I, Shim JH, Steinman V, Bode AM, Dong Z
PLoS One 4 e8044 (2009)
PMID: 19956600

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-3 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 37.48 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18654 (Residues: 44-367; Coverage: 44%)
Gene names: Mapkapk1b, Rps6ka-rs1, Rps6ka3, Rsk2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 51.167Å b: 51.381Å c: 140.873Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.204 0.248
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
1 more

13 mentions without citation

The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.
Utepbergenov et al. (2013)
12 more