› 3g8g

X-ray diffraction
1.7Å resolution

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 ammodytoxin A Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.81 KDa
Source organism: Vipera ammodytes ammodytes
Expression system: Escherichia coli
UniProt:
  • Canonical: P00626 (Residues: 17-138; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P321
Unit cell:
a: 68.19Å b: 68.19Å c: 46.08Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.172 0.216
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Understanding the molecular mechanism underlying the presynaptic toxicity of secreted phospholipases A(2): an update.
Šribar et al. (2014)
4 more

5 mentions without citation

Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.
Kudryavtsev et al. (2015)
4 more