› 3g9r

X-ray diffraction
2Å resolution

Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation

Released:
DOI: 10.2210/pdb3g9r/pdb
PDB entry 3g9r coloured by chain, front view.
PDB entry 3g9r coloured by chain, side view.
PDB entry 3g9r coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the HIV-1 gp41 membrane-proximal ectodomain region in a putative prefusion conformation.
Liu J, Deng Y, Dey AK, Moore JP, Lu M
Biochemistry 48 2915-23 (2009)
PMID: 19226163

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136497 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General control transcription factor GCN4; Transmembrane protein gp41 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 42 amino acids
Theoretical weight: 5.42 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P03377 (Residues: 667-689; Coverage: 3%)
  • Canonical: P03069 (Residues: 258-276; Coverage: 7%)
Gene names: AAS101, AAS3, ARG9, GCN4, YEL009C, env
Sequence domains: Basic region leucine zipper
Structure domains: Single helix bin

Ligands and Environments

2 bound ligands:
Ligand PO4 5 x PO4
Ligand MPD 8 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 42.527Å b: 48.157Å c: 81.782Å
α: 90° β: 95.38° γ: 90°
R-values:
R R work R free
0.216 0.213 0.269
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Challenges for structure-based HIV vaccine design.
Schief et al. (2009)
7 more

6 mentions without citation

Structure of the HIV-1 gp41 membrane-proximal ectodomain region in a putative prefusion conformation.
Liu et al. (2009)
5 more