› 3geu

X-ray diffraction
1.9Å resolution

Crystal Structure of IcaR from Staphylococcus aureus, a member of the tetracycline repressor protein family

Released:
DOI: 10.2210/pdb3geu/pdb
PDB entry 3geu coloured by chain, front view.
PDB entry 3geu coloured by chain, side view.
PDB entry 3geu coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus COL
Entry authors: Anderson SM, Brunzelle JS, Wawrzak Z, Skarina T, Papazisi L, Anderson WF, Savchenko A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 189 amino acids
Theoretical weight: 22.52 KDa
Source organism: Staphylococcus aureus subsp. aureus COL
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5HCN2 (Residues: 1-186; Coverage: 100%)
Gene names: SACOL2688, icaR
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

3 bound ligands:
Ligand CL 5 x CL
Ligand FMT 10 x FMT
Ligand NA 1 x NA
1 modified residue:
Ligand MSE 20 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21212
Unit cell:
a: 113.922Å b: 121.141Å c: 61.686Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.228
Expression system: Escherichia coli

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