› 3gg2

X-ray diffraction
1.7Å resolution

Crystal structure of UDP-glucose 6-dehydrogenase from Porphyromonas gingivalis bound to product UDP-glucuronate

Released:
DOI: 10.2210/pdb3gg2/pdb
PDB entry 3gg2 coloured by chain, front view.
PDB entry 3gg2 coloured by chain, side view.
PDB entry 3gg2 coloured by chain, top view.
Source organism: Porphyromonas gingivalis
Entry authors: Bonanno JB, Freeman J, Bain KT, Chang S, Sampathkumar P, Wasserman S, Sauder JM, Burley SK, Almo SC, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucose 6-dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 450 amino acids
Theoretical weight: 49.92 KDa
Source organism: Porphyromonas gingivalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7MVC7 (Residues: 80-518; Coverage: 84%)
Gene name: PG_1143
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand UGA 6 x UGA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 82.365Å b: 143.489Å c: 85.501Å
α: 90° β: 112.46° γ: 90°
R-values:
R R work R free
0.217 0.215 0.256
Expression system: Escherichia coli

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