› 3gg6

X-ray diffraction
2.1Å resolution

Crystal structure of the NUDIX domain of human NUDT18

Released:
DOI: 10.2210/pdb3gg6/pdb
PDB entry 3gg6 coloured by chain, front view.
PDB entry 3gg6 coloured by chain, side view.
PDB entry 3gg6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Siponen MI, Lehtio L, Arrowsmith CH, Berglund H, Bountra C, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Moche M, Nilsson ME, Nyman T, Persson C, Sagemark J, Schueler H, Thorsell AG, Van Den Berg S, Weigelt J, Welin M, Wisniewska M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
8-oxo-GDP + H(2)O = 8-oxo-GMP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
8-oxo-dGDP phosphatase NUDT18 Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZVK8 (Residues: 26-179; Coverage: 48%)
Gene names: MTH3, NUDT18
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 31.66Å b: 60.13Å c: 76.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.164 0.226
Expression system: Escherichia coli

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