› 3gh6

X-ray diffraction
1.65Å resolution

Crystal Structure of Glutathione Transferase dmgstd10 from Drosophila melanogaster, in complex with glutathione

Released:
DOI: 10.2210/pdb3gh6/pdb
PDB entry 3gh6 coloured by chain, front view.
PDB entry 3gh6 coloured by chain, side view.
PDB entry 3gh6 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural evidence for conformational changes of Delta class glutathione transferases after ligand binding.
Wongsantichon J, Robinson RC, Ketterman AJ
Arch Biochem Biophys 521 77-83 (2012)
PMID: 22475449

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194247 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IP02193p Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 24.62 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VGA1 (Residues: 1-210; Coverage: 100%)
Gene names: CG17392, CG18548, DmGSTD10, Dmel\CG18548, Dmel_CG18548, GSTD10, GstD10, gstd10
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: I212121
Unit cell:
a: 73.309Å b: 87.225Å c: 105.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.197
Expression system: Escherichia coli

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Citations

7 citation in other articles

Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus.
Roberts et al. (2013)
6 more