› 3gm0

X-ray diffraction
2.4Å resolution

Anti-methamphetamine single chain Fv in complex with MDMA

Released:
DOI: 10.2210/pdb3gm0/pdb
PDB entry 3gm0 coloured by chain, front view.
PDB entry 3gm0 coloured by chain, side view.
PDB entry 3gm0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
Celikel R, Peterson EC, Owens SM, Varughese KI
Protein Sci 18 2336-45 (2009)
PMID: 19760665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213264 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
anti-methamphetamine single chain Fv Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 27.79 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand B41 1 x B41
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P21
Unit cell:
a: 34.72Å b: 64.806Å c: 48.322Å
α: 90° β: 98.97° γ: 90°
R-values:
R R work R free
0.214 0.214 0.271
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Pharmacokinetic strategies for treatment of drug overdose and addiction.
Gorelick DA. (2012)
1 more

1 mention without citation

Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
Celikel et al. (2009)