› 3gue

X-ray diffraction
1.92Å resolution

Crystal Structure of UDP-glucose phosphorylase from Trypanosoma Brucei, (Tb10.389.0330)

Released:
DOI: 10.2210/pdb3gue/pdb
Model geometry
Fit model/data
PDB entry 3gue coloured by chain, front view.
PDB entry 3gue coloured by chain, side view.
PDB entry 3gue coloured by chain, top view.
Source organism: Trypanosoma brucei
Entry authors: Wernimont AK, Marino K, Lin YH, Mackenzie F, Kozieradzki I, Cossar D, Zhao Y, Schapira M, Bochkarev A, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Ferguson MAJ, Hui R, Amani M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UTP--glucose-1-phosphate uridylyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 484 amino acids
Theoretical weight: 54.31 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q388T4 (Residues: 3-485; Coverage: 100%)
Gene name: Tb10.389.0330
Sequence domains: UTP--glucose-1-phosphate uridylyltransferase
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand UPG 2 x UPG
Ligand GOL 5 x GOL
Ligand SO4 7 x SO4
Ligand DTU 1 x DTU
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 167.697Å b: 77.485Å c: 112.209Å
α: 90° β: 117.88° γ: 90°
R-values:
R R work R free
0.243 0.241 0.294
Expression system: Escherichia coli

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