› 3gwo

X-ray diffraction
1.65Å resolution

Structure of the C-terminal Domain of a Putative HIV-1 gp41 Fusion Intermediate

Released:
DOI: 10.2210/pdb3gwo/pdb
PDB entry 3gwo coloured by chain, front view.
PDB entry 3gwo coloured by chain, side view.
PDB entry 3gwo coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Primary publication:
Role of a putative gp41 dimerization domain in human immunodeficiency virus type 1 membrane fusion.
Liu J, Deng Y, Li Q, Dey AK, Moore JP, Lu M
J Virol 84 201-9 (2010)
PMID: 19846514

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B
Molecule details ›
Chains: A, B
Length: 54 amino acids
Theoretical weight: 6.85 KDa
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Escherichia coli
UniProt:
  • Canonical: Q70626 (Residues: 630-683; Coverage: 7%)
Gene name: env
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
Ligand JEF 2 x JEF
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3121
Unit cell:
a: 33.957Å b: 33.957Å c: 174.838Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.232 0.259
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design.
Cai et al. (2011)
11 other articles

2 mentions without citation

Structural characterization of HIV gp41 with the membrane-proximal external region.
Shi et al. (2010)
1 more