› 3gz9

X-ray diffraction
2Å resolution

Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist

Released:
DOI: 10.2210/pdb3gz9/pdb
PDB entry 3gz9 coloured by chain, front view.
PDB entry 3gz9 coloured by chain, side view.
PDB entry 3gz9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
Connors RV, Wang Z, Harrison M, Zhang A, Wanska M, Hiscock S, Fox B, Dore M, Labelle M, Sudom A, Johnstone S, Liu J, Walker NP, Chai A, Siegler K, Li Y, Coward P
Bioorg Med Chem Lett 19 3550-4 (2009)
PMID: 19464171

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 171-439; Coverage: 61%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand B7G 1 x B7G
Ligand D32 1 x D32
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 94.577Å b: 92.129Å c: 39.555Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.245
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The retinoid X receptors and their ligands.
Dawson et al. (2012)
2 more

13 mentions without citation

Activation of PPARĪ“: from computer modelling to biological effects.
Kahremany et al. (2015)
12 more