› 3gzl

X-ray diffraction
2.55Å resolution

Crystal Structure of holo PfACP Disulfide-Linked Dimer

Released:
DOI: 10.2210/pdb3gzl/pdb
PDB entry 3gzl coloured by chain, front view.
PDB entry 3gzl coloured by chain, side view.
PDB entry 3gzl coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth.
Gallagher JR, Prigge ST
Proteins 78 575-88 (2010)
PMID: 19768685

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl carrier protein Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.19 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: O77077 (Residues: 57-137; Coverage: 67%)
Gene name: acpP
Sequence domains: Phosphopantetheine attachment site
Structure domains: ACP-like

Ligands and Environments

1 bound ligand:
Ligand PNS 1 x PNS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: I41
Unit cell:
a: 48.675Å b: 48.675Å c: 97.588Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.241 0.267
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Antimalarial drugs and drug targets specific to fatty acid metabolic pathway of Plasmodium falciparum.
Qidwai et al. (2012)
1 more

2 mentions without citation

Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth.
Gallagher et al. (2010)
1 more