› 3h8z

X-ray diffraction
1.92Å resolution

The Crystal Structure of the Tudor Domains from FXR2

Released:
DOI: 10.2210/pdb3h8z/pdb
PDB entry 3h8z coloured by chain, front view.
PDB entry 3h8z coloured by chain, side view.
PDB entry 3h8z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J
PLoS One 5 e13559 (2010)
PMID: 21072162

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156290 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein FXR2 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51116 (Residues: 13-136; Coverage: 18%)
Gene names: FMR1L2, FXR2
Sequence domains:
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 34.563Å b: 54.676Å c: 70.171Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.25
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Molecular mechanisms of fragile X syndrome: a twenty-year perspective.
Santoro et al. (2012)
9 more

4 mentions without citation

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Adams-Cioaba et al. (2010)
3 more