› 3ha7

X-ray diffraction
2.35Å resolution

Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with S-adenosyl-N-decyl-aminoethyl (SADAE)

Released:
DOI: 10.2210/pdb3ha7/pdb
PDB entry 3ha7 coloured by chain, front view.
PDB entry 3ha7 coloured by chain, side view.
PDB entry 3ha7 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Vaubourgeix J, Boissier F, Julien S, Mourey L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydroxymycolate synthase MmaA4 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.52 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: Q79FX8 (Residues: 4-301; Coverage: 99%)
Gene names: Rv0642c, hma, mma4, mmaA4
Sequence domains: Mycolic acid cyclopropane synthetase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

1 bound ligand:
Ligand B32 1 x B32
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 57.429Å b: 57.429Å c: 205.079Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.211 0.243
Expression system: Escherichia coli

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