› 3hah

X-ray diffraction
2.77Å resolution

Crystal structure of human PACSIN1 F-BAR domain (C2 lattice)

Released:
DOI: 10.2210/pdb3hah/pdb
PDB entry 3hah coloured by chain, front view.
PDB entry 3hah coloured by chain, side view.
PDB entry 3hah coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Wang Q, Navarro MV, Peng G, Molinelli E, Goh SL, Judson BL, Rajashankar KR, Sondermann H
Proc Natl Acad Sci U S A 106 12700-5 (2009)
PMID: 19549836

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C and casein kinase substrate in neurons protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 38.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BY11 (Residues: 1-325; Coverage: 73%)
Gene names: KIAA1379, PACSIN1
Sequence domains: Fes/CIP4, and EFC/F-BAR homology domain
Structure domains: Arfaptin homology (AH) domain/BAR domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 160.009Å b: 85.457Å c: 88.392Å
α: 90° β: 117.56° γ: 90°
R-values:
R R work R free
0.217 0.215 0.26
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Dynamin, a membrane-remodelling GTPase.
Ferguson et al. (2012)
34 more

5 mentions without citation

Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Wang et al. (2009)
4 more