› 3haj

X-ray diffraction
2.78Å resolution

Crystal structure of human PACSIN2 F-BAR domain (p212121 lattice)

Released:
DOI: 10.2210/pdb3haj/pdb
PDB entry 3haj coloured by chain, front view.
PDB entry 3haj coloured by chain, side view.
PDB entry 3haj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Wang Q, Navarro MV, Peng G, Molinelli E, Goh SL, Judson BL, Rajashankar KR, Sondermann H
Proc Natl Acad Sci U S A 106 12700-5 (2009)
PMID: 19549836

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193992 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C and casein kinase substrate in neurons protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 486 amino acids
Theoretical weight: 55.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UNF0 (Residues: 1-486; Coverage: 100%)
Gene name: PACSIN2
Sequence domains:
Structure domains: Arfaptin homology (AH) domain/BAR domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 31.295Å b: 88.395Å c: 357.722Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.274
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Dynamin, a membrane-remodelling GTPase.
Ferguson et al. (2012)
34 more

3 mentions without citation

Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Wang et al. (2009)
2 more