› 3hbw

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Fibroblast Growth Factor Homologous Factor 2A (FHF2A), also referred to as Fibroblast Growth Factor 13A (FGF13A)

Released:
DOI: 10.2210/pdb3hbw/pdb
PDB entry 3hbw coloured by chain, front view.
PDB entry 3hbw coloured by chain, side view.
PDB entry 3hbw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
Goetz R, Dover K, Laezza F, Shtraizent N, Huang X, Tchetchik D, Eliseenkova AV, Xu CF, Neubert TA, Ornitz DM, Goldfarb M, Mohammadi M
J Biol Chem 284 17883-96 (2009)
PMID: 19406745

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 21.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92913 (Residues: 53-245; Coverage: 79%)
Gene names: FGF13, FHF2
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 52.218Å b: 57.998Å c: 52.236Å
α: 90° β: 93.79° γ: 90°
R-values:
R R work R free
0.219 0.219 0.251
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The Fibroblast Growth Factor signaling pathway.
Ornitz et al. (2015)
20 more

8 mentions without citation

Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.
Wang et al. (2012)
7 more