› 3hi5

X-ray diffraction
2.5Å resolution

Crystal structure of Fab fragment of AL-57

Released:
DOI: 10.2210/pdb3hi5/pdb
PDB entry 3hi5 coloured by chain, front view.
PDB entry 3hi5 coloured by chain, side view.
PDB entry 3hi5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1.
Zhang H, Liu JH, Yang W, Springer T, Shimaoka M, Wang JH
Proc Natl Acad Sci U S A 106 18345-50 (2009)
PMID: 19805116

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213269 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heavy chain of Fab fragment of AL-57 against alpha L I domain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
light chain of Fab fragment of AL-57 against alpha L I domain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6122
Unit cell:
a: 84.74Å b: 84.74Å c: 317.17Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.277
Expression system: Cricetulus griseus

Quick links

Citations

10 citation in other articles

Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1.
Yuki et al. (2010)
9 more

9 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
8 more