› 3hlp

X-ray diffraction
1.6Å resolution

Carboxypeptidase A liganded to an organic small-molecule: conformational changes

Released:
DOI: 10.2210/pdb3hlp/pdb
PDB entry 3hlp coloured by chain, front view.
PDB entry 3hlp coloured by chain, side view.
PDB entry 3hlp coloured by chain, top view.
Source organism: Bos taurus
Entry author: Fernandez D

Function and Biology Details

Reaction catalysed: 
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107846 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 34.72 KDa
Source organism: Bos taurus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: A6H6Y4 (Residues: 111-419; Coverage: 77%)
Gene name: CPA1
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand MRD 3 x MRD
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 64.79Å b: 59.933Å c: 72.457Å
α: 90° β: 99.47° γ: 90°
R-values:
R R work R free
0.158 0.158 0.181
Expression system: Komagataella pastoris

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