› 3hlt

X-ray diffraction
2.3Å resolution

The crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2)

Released:
DOI: 10.2210/pdb3hlt/pdb
PDB entry 3hlt coloured by chain, front view.
PDB entry 3hlt coloured by chain, side view.
PDB entry 3hlt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Shafqat N, Yue WW, Cocking R, Bray JE, Muniz JRC, Krojer T, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-190487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Haloacid dehalogenase-like hydrolase domain-containing protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 266 amino acids
Theoretical weight: 29.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H0R4 (Residues: 1-259; Coverage: 100%)
Gene name: HDHD2
Sequence domains:
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand CL 2 x CL
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Unit cell:
a: 68.94Å b: 77.68Å c: 103.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.266
Expression system: Escherichia coli

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