› 3hmh

X-ray diffraction
2.05Å resolution

Crystal structure of the second bromodomain of human TBP-associated factor RNA polymerase 1-like (TAF1L)

Released:
DOI: 10.2210/pdb3hmh/pdb
PDB entry 3hmh coloured by chain, front view.
PDB entry 3hmh coloured by chain, side view.
PDB entry 3hmh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-184977 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription initiation factor TFIID subunit 1-like Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 18.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZX4 (Residues: 1523-1654; Coverage: 7%)
Gene name: TAF1L
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P3221
Unit cell:
a: 55.139Å b: 55.139Å c: 84.441Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.181 0.252
Expression system: Escherichia coli

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

7 mentions without citation

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations.
Aldeghi et al. (2017)
6 more