› 3hpk

X-ray diffraction
2.2Å resolution

Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GluR2

Released:
DOI: 10.2210/pdb3hpk/pdb
PDB entry 3hpk coloured by chain, front view.
PDB entry 3hpk coloured by chain, side view.
PDB entry 3hpk coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Redox-regulated lipid membrane binding of the PICK1 PDZ domain.
Shi Y, Yu J, Jia Y, Pan L, Shen C, Xia J, Zhang M
Biochemistry 49 4432-9 (2010)
PMID: 20426484

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-190148 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PRKCA-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 13.39 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9EP80 (Residues: 1-110; Coverage: 26%)
Gene names: Pick1, Prkcabp
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 49.26Å b: 51.79Å c: 80.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.235
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Plasticity of PDZ domains in ligand recognition and signaling.
Ivarsson Y. (2012)
2 more

3 mentions without citation

Membrane Binding and Modulation of the PDZ Domain of PICK1.
Erlendsson et al. (2015)
2 more