› 3hqc

X-ray diffraction
1.8Å resolution

Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)

Released:
DOI: 10.2210/pdb3hqc/pdb
PDB entry 3hqc coloured by chain, front view.
PDB entry 3hqc coloured by chain, side view.
PDB entry 3hqc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sampathkumar P, Romero R, Wasserman S, Do J, Dickey M, Bain K, Gheyi T, Klemke R, Atwell S, Sauder JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tensin-2 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q63HR2 (Residues: 1264-1409; Coverage: 10%)
Gene names: KIAA1075, TENC1, TNS2
Sequence domains: Phosphotyrosine-binding domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand ACT 2 x ACT
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P65
Unit cell:
a: 108.909Å b: 108.909Å c: 36.196Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.242
Expression system: Escherichia coli BL21(DE3)

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