› 3hsy

X-ray diffraction
1.75Å resolution

High resolution structure of a dimeric GluR2 N-terminal domain (NTD)

Released:
DOI: 10.2210/pdb3hsy/pdb
PDB entry 3hsy coloured by chain, front view.
PDB entry 3hsy coloured by chain, side view.
PDB entry 3hsy coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
Rossmann M, Sukumaran M, Penn AC, Veprintsev DB, Babu MM, Greger IH
EMBO J 30 959-71 (2011)
PMID: 21317873

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 376 amino acids
Theoretical weight: 42.52 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P19491 (Residues: 25-400; Coverage: 44%)
Gene names: GluA2, Glur2, Gria2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 82.452Å b: 93.695Å c: 101.466Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 0.205
Expression system: Spodoptera frugiperda

Quick links

Citations

23 review citations

Synaptic AMPA receptor composition in development, plasticity and disease.
Henley et al. (2016)
22 more

10 mentions without citation

The significance of G protein-coupled receptor crystallography for drug discovery.
Salon et al. (2011)
9 more