› 3i2v

X-ray diffraction
1.25Å resolution

Crystal structure of human MOCS3 rhodanese-like domain

Released:
DOI: 10.2210/pdb3i2v/pdb
PDB entry 3i2v coloured by chain, front view.
PDB entry 3i2v coloured by chain, side view.
PDB entry 3i2v coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bacik JP, Walker JR, Lopez L, Li Y, Weigelt J, Bountra C, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + [cysteine desulfurase] + oxidized acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylyltransferase and sulfurtransferase MOCS3 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95396 (Residues: 335-460; Coverage: 27%)
Gene names: MOCS3, UBA4
Sequence domains: Rhodanese-like domain
Structure domains: Rhodanese-like domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 36.817Å b: 31.911Å c: 50.64Å
α: 90° β: 110.16° γ: 90°
R-values:
R R work R free
0.161 0.159 0.204
Expression system: Escherichia coli

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