› 3ibh

X-ray diffraction
2.1Å resolution

Crystal structure of Saccharomyces cerevisiae Gtt2 in complex with glutathione

Released:
DOI: 10.2210/pdb3ibh/pdb
PDB entry 3ibh coloured by chain, front view.
PDB entry 3ibh coloured by chain, side view.
PDB entry 3ibh coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.
Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ
EMBO Rep 10 1320-6 (2009)
PMID: 19851333

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase 2 Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 26.38 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12390 (Residues: 1-233; Coverage: 100%)
Gene names: GTT2, L0560, YLL060C
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 88.774Å b: 88.774Å c: 69.102Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.247
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Mitochondrial Glutathione: Regulation and Functions.
Calabrese et al. (2017)
14 other articles

1 mention without citation

Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.
Ma et al. (2009)