› 3idv

X-ray diffraction
1.95Å resolution

Crystal structure of the a0a fragment of ERp72

Released:
DOI: 10.2210/pdb3idv/pdb
PDB entry 3idv coloured by chain, front view.
PDB entry 3idv coloured by chain, side view.
PDB entry 3idv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the catalytic a(0)a fragment of the protein disulfide isomerase ERp72.
Kozlov G, Azeroual S, Rosenauer A, Määttänen P, Denisov AY, Thomas DY, Gehring K
J Mol Biol 401 618-25 (2010)
PMID: 20600112

Function and Biology Details

Reaction catalysed: 
Catalyzes the rearrangement of -S-S- bonds in proteins
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein disulfide-isomerase A4 Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 26.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P13667 (Residues: 53-284; Coverage: 37%)
Gene names: ERP70, ERP72, PDIA4
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P41212
Unit cell:
a: 54.883Å b: 54.883Å c: 166.497Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.246
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

A structural overview of the PDI family of proteins.
Kozlov et al. (2010)
2 more

5 mentions without citation

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation.
Chiu et al. (2019)
4 more