› 3igq

X-ray diffraction
2.3Å resolution

Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel

Released:
DOI: 10.2210/pdb3igq/pdb
PDB entry 3igq coloured by chain, front view.
PDB entry 3igq coloured by chain, side view.
PDB entry 3igq coloured by chain, top view.
Source organism: Gloeobacter violaceus
Primary publication:
Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel.
Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M
J Mol Biol 395 1114-27 (2010)
PMID: 19917292

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181807 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proton-gated ion channel Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 201 amino acids
Theoretical weight: 22.87 KDa
Source organism: Gloeobacter violaceus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7NDN8 (Residues: 44-235; Coverage: 61%)
Gene names: glr4197, glvI
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

4 bound ligands:
Ligand ACY 6 x ACY
Ligand NA 6 x NA
Ligand HG 6 x HG
Ligand CL 6 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 84.45Å b: 130.24Å c: 113.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.255
Expression system: Escherichia coli

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Citations

11 review citations

The structural basis of function in Cys-loop receptors.
Thompson et al. (2010)
10 more